The effectiveness and safety of diode laser hair removal have been confirmed by dermatologists around the world.

This technique is suitable for all skin types, non-invasive, no down time, economical and reliable, and is considered as a gold standard for hair removal.

Non-invasive & Rejuvenation and Skin Remodeling

Mesotherapy

Transdermal drug delivery technology

Transdermal delivery offers advantages such as noninvasiveness and the ability to overcome first-pass hepatic metabolism. Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier.

In recent years various passive and active strategies have emerged to optimize transdermal delivery. The passive approach entails the optimization of formulation or drug carrying vehicle to increase skin permeability. It has been demonstrated that passive methods do not greatly improve the permeation of drugs with molecular weights >500 Da. In contrast active methods, normally involving physical or mechanical methods of enhancing delivery have been shown to be generally superior.

The delivery of drugs of differing lipophilicity and molecular weight including proteins, peptides, and oligonucletides has been shown to be improved by active methods such as iontophoresis, electroporation, microchip, derma pen and other energy-related techniques.

Introduction of Electroporation for transdermal drug delivery

The use of electropermeabilization, as a method of enhancing diffusion across biological barriers, dates back as far as 100 years.

Electroporation involves the application of high voltage pulses to induce skin perturbation.
High voltages and short treatment durations are most frequently employed. Other electrical parameters that affect delivery include pulse properties such as waveform, rate and number. The increase in skin permeability is suggested to be caused by the generation of transient pores during
electroporation.

The technology has been successfully used to enhance the skin permeability of molecules with differing lipophilicity and size including biopharmaceuticals with a molecular weight greater than 7kDA, the current limit for iontophoresis.

Introduction of hollow Microchip for transdermal drug delivery

The microchip is a patch with short microneedle array, usually the height of microchip is not more than 500μm, the overarching motivation for microchip is that they can provide a minimally invasive means to transport molecules into the skin.

Although the microchip concept was proposed in the 1970s, most work had been focused on making microscopic holes in the skin by inserting solid microchips made of silicon or metal. It was not demonstrated experimentally until the 1990s when the microelectronics industry provided the microfabrication tools needed to make such small structures.

Since the first studies of transdermal drug delivery in 1998, there has been rapidly increasing interest in the field, with most activity in the microfabrication community to develop novel microchip fabrication technologies and the drug delivery industry to develop microchips for pharmaceutical applications.

With the development of laser micromachining technology, hollow microchip designs and methods have also been studied using an approach more reminiscent of an injection than a transdermal poke.

Although harder to make, the hollow microchips offer the possibility of transporting drugs through the interior of well-defined needles by diffusion or, for more rapid rates of delivery, by pressure-driven flow.

EPM Technology

EPM technology combined the electroporation with hollow microchip technologies for transdermal drug delivery. Since the EPM concept was first put forward by Wingderm® in 2017, it has attracted wide attention.

The patent Mesoskin© mesotherapy device designed by Wingderm® with EPM technology has been widely used in medical and aesthetic filed and is validated by more than 100 million people around the world. It is recommended and experienced everyday by people of different languages and skin tones all over the world.


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